TCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt . TCL1(10-24) inhibits cellular proliferation and anti-apoptosis . TCL1(10-24) has tumor growth in vivo.
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