PKHB1

Overview

PKHB1 (txCD47) is a CD47 agonist and Thrombospondin-1 peptide mimetic. PKHB1 activates CD47 and triggers Caspase -independent, calcium-dependent cell death via mitochondrial alterations, ROS production, endoplasmic reticulum morphological changes, and dissipation of mitochondrial membrane potential. PKHB1 induces the exposure of Calreticulin , HSP70 , and HSP90 , thereby driving immunogenic cell death. PKHB1 promotes intratumoral CD8 + T cell infiltration and inhibits breast tumorigenesis. PKHB1 reduces HSV-1 levels and alleviates the severity of herpes simplex keratitis. PKHB1 can be used in research related to breast cancer , herpes simplex keratitis, and T-cell acute lymphoblastic leukemia.

Application

Products | Products > Peptides | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Viral Infection | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Lymphoblastic Leukemia | Products > Disease Areas > HSV Infection | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HSP | Products > Signaling Pathways > HSV | Products > Signaling Pathways > CD47 | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Thrombopoietin Receptor | Products > Signaling Pathways > Mitochondrial Metabolism

Product Information

• Catalog No.: HY-P10371
• CAS No.: 1505523-99-8
• Molecular Formula: C68H105N17O12S
• Molecular Weight: 1384.73
• Purity: 99.84%
• Storage: Sealed storage, away from moisture. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source