cyclo(CLLFVY)

Overview

cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 ( HIF-1 ), with IC 50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α , inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers.

Application

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Product Information

• Catalog No.: HY-P10426
• CAS No.: 1446322-73-1
• Molecular Formula: C38H54N6O7S
• Molecular Weight: 738.94
• Purity: 99.37%
• Storage: Sealed storage, away from moisture. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source