CPI1

Overview

CPI1 is a multidrug resistance protein 1 ( MRP1 ) inhibitor with a K i value of 100 nM. CPI1 binds to the same substrate-binding site as leukotriene C 4 , stabilizes MRP1 in an apo-like inward-facing conformation, blocks the conformational changes required for ATP hydrolysis and substrate transport, and inhibits the ATPase activity of human and bovine MRP1 . CPI1 serves as a tool for investigating the substrate transport mechanism of MRP1 . CPI1 is applicable to research related to cancer multidrug resistance.

Application

Products | Products > Peptides | Products > Disease Areas > Cancer | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > P-glycoprotein

Product Information

• Catalog No.: HY-P10856
• CAS No.: 3085809-95-3
• Molecular Formula: C111H131N23O30S
• Molecular Weight: 2299.43
• Purity: 99.30%
• Storage: Sealed storage, away from moisture. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (1.09 mM); Clear solution
• Availability: In-stock

Source

Original product source