Oncocin is an antibacterial peptide. It belongs to proline-rich antimicrobial peptides ( PrAMPs ). Oncocin works against Gram-negative bacteria. It has MIC values of 0.125-8 μg/mL for 34 strains and clinical isolates of Enterobacteriaceae and nonfermenters. Oncocin binds to the substrate-binding domain of the chaperone DnaK . The binding has dissociation constants in the micromolar range. This binding causes protein misfolding and aggregation and the bacteria death.
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