WT1 126-134 peptide is a Wilms' tumor oncogene protein ( WT1 ) peptide (RMFPNAPYL). WT1 126-134 peptide is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide/HLA-A0201 complex has an extremely high affinity ( K d = 0.2 nM) with the humanized monoclonal antibody ( IgG1 ). WT1 126-134 peptide can be used as a vaccine for T cells or as a target for antibodies.
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