Periplanetasin-4

Overview

Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach ( Periplaneta americana ). Periplanetasin-4 reduces cell rounding and apoptosis . Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21 . Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis.

Application

Products | Products > Peptides | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Clostridium Difficile Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-P11114
• CAS No.: 2206807-06-7
• Molecular Formula: C70H110N20O15S
• Molecular Weight: 1503.81
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source