NAB815

Overview

NAB815 is a specific inhibitor of the Stx2a ( K d = 0.01 μM)/ TLR4 interaction. NAB815 inhibits the neutrophil/Stx2a interaction ( IC 50 = 0.057 μg/mL). NAB815 inhibits the formation of Stx2-containing extracellular vesicles (EVs) produced by leukocytes and platelets and reduces their toxic effects in cellular (Vero cells) and animal models (CD-1 mice). NAB815 reduces bacterial loads in the kidneys, urine, and bladders of Escherichia coli-infected mice. NAB815 is useful in the study of hemolytic uremic syndrome (HUS).

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-P11232
• CAS No.: 1969250-99-4
• Molecular Formula: C55H94N14O14
• Molecular Weight: 1175.42
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source