CCKBR agonist-1

Overview

CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor ( CCKBR ) agonist with an EC 50 of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC 50 of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase ( ADAM10 ) and calcium signaling molecule PLCB4 , reduce the number of amyloid β ( Aβ ) plaques, and promote long-term potentiation (LTP). CCKBR agonist-1 can be used for the study of Alzheimer's disease.

Application

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Product Information

• Catalog No.: HY-P11540
• CAS No.: 2923120-30-1
• Molecular Formula: C32H39BrN6O7
• Molecular Weight: 699.59
• Purity: 98.48%
• Storage: Sealed storage, away from moisture. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (3.57 mM); Clear solution
• Availability: In-stock

Source

Original product source