A20FMDV2 is a highly selective αvβ6 integrin inhibitor with human IC 50 values of 3 nM and binds with at least 1000-fold selectivity over other RGD-binding integrins . A20FMDV2 binds to the integrin’s RGD-binding site, induces rapid integrin internalization, and delays post-internalization integrin recycling to the cell surface. A20FMDV2 can be used for the research of pancreatic cancer , breast cancer , colorectal cancer , ovarian cancer , oral squamous cell carcinoma.
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