Spexin

Overview

Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3 , and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy , reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride ( HY-15142 )-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy.

Application

Products | Products > Peptides | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Neuropeptide Y Receptor | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-P1723
• CAS No.: 1370290-58-6
• Molecular Formula: C74H114N20O19S
• Molecular Weight: 1619.88
• Purity: 99.12%
• Storage: Sealed storage, away from moisture and light. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source