TRV-120027

Overview

TRV120027, a β-arrestin-1 -biased agonist of the angiotensin II receptor type 1 (AT1R) , engages β-arrestins while blocking G-protein signaling. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R-β-arrestin-1-TRPC3-PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment.

Application

Products | Products > Peptides | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Angiotensin Receptor | Products > Signaling Pathways > Arrestin

Product Information

• Catalog No.: HY-P2141
• CAS No.: 1234510-46-3
• Molecular Formula: C43H67N13O10
• Molecular Weight: 926.07
• Purity: 98.21%
• Storage: Sealed storage, away from moisture and light, under nitrogen. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
• Availability: In-stock

Source

Original product source