TRV055

Overview

TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors ( AT1Rs ). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2 . TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses [1] For research use only. We do not sell to patients. Purity: 99.47% CAS No.: 25849-90-5 Formula: C 42 H 57 N 9 O 9 Molecular Weight: 831.96 Storage: Sealed storage, away from moisture and light, under nitrogen. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) Data Sheet (276 KB) SDS COA Custom Peptide Synthesis

Application

Products | Products > Peptides | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Angiotensin Receptor | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-P3136
• CAS No.: 25849-90-5
• Molecular Formula: C42H57N9O9
• Molecular Weight: 831.96
• Purity: 99.47%
• Storage: Sealed storage, away from moisture and light, under nitrogen. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
• Availability: In-stock

Source

Original product source