LL-37 amide

Overview

LL-37 amide is a selective agonist of formyl peptide receptor-like FPRL1 , effectively inhibiting periodontal pathogens (ED 99 =8.5-8.7 μg/mL). LL-37 amide exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing.

Application

Products | Products > Peptides | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Signaling Pathways > Formyl Peptide Receptor (FPR) | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-P4744
• CAS No.: 597562-32-8
• Molecular Formula: C205H341N61O52
• Molecular Weight: 4492.28
• Purity: 99.77%
• Storage: Sealed storage, away from moisture. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source