Spiradoline (U-62066), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a K i of 8.6 nM in guinea pig. The K i values of Spiradoline for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier.
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