Oxodipine, a dihydropyridine-type calcium antagonist, inhibits KCl-induced aortic contraction in rabbits and reduces cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduces L-type Ca currents (I) with an IC 50 of 0.24 μM, and against T-type Ca currents (I) with an IC 50 of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs.
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