BMP2-derived peptide

Overview

BMP2-derived peptide is an osteogenic inducer and BMP receptor ligand. BMP2-derived peptide binds to BMP receptors on the cell surface to form a complex, activates the downstream Smad signaling pathway, and regulates the expression of osteogenic transcription factors. BMP2-derived peptide effectively promotes the adhesion, proliferation, osteogenic differentiation and mineralization of bone marrow mesenchymal stem cells, significantly up-regulates the mRNA levels of OCN, Runx2 and type I collagen , and increases alkaline phosphatase activity and calcium deposition. BMP2-derived peptide induces osteoblast differentiation and ectopic bone regeneration, and improves cranial bone defect repair. Meanwhile, BMP2-derived peptide enhances the cytocompatibility of mesoporous silica nanoparticles, synergistically increases osteogenic activity with Dexamethasone ( HY-14648 ), serving as an important tool for bone defect repair research.

Application

Products | Products > Peptides | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Osteogenic Differentiation | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > RUNX

Product Information

• Catalog No.: HY-P5832
• CAS No.: 836606-84-9
• Molecular Formula: C97H165N23O29
• Molecular Weight: 2117.48
• Purity: 98.04%
• Storage: Sealed storage, away from moisture and light. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source