Nemazoline hydrochloride (A-57219 hydrochloride) is selective α-adrenergic agent with α 1 -agonist/ α 2 -antagonist activity, which is used as a nasal decongestant. Nemazoline hydrochloride produces decongestion by α 1 -mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α 2 -antagonism. Nemazoline hydrochloride also blocks endogenous noradrenaline-mediated α 2 -constriction of the resistance vessels.
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