Tigemonam

Overview

Tigemonam is an orally active monobactam antibiotic with a K i of 0.86 μM against Enterobacter cloacae P99 β-lactamase and 50.8 μM against Escherichia coli TEM-1 β-lactamase. Tigemonam binds to penicillin-binding proteins 1a, 3, and 4, inhibits bacterial cell wall synthesis, and exhibits bactericidal activity against aerobic gram-negative bacteria including Enterobacteriaceae , Haemophilus influenzae , and Neisseria gonorrhoeae . Tigemonam resists hydrolysis by multiple β-lactamase enzymes , reduces bacterial load in systemic, pyelonephritic, lung, and thigh muscle infections in rodents, and shows minimal difference between minimum inhibitory and bactericidal concentrations. Tigemonam can be used for the research of gram-negative bacterial infections, acute pyelonephritis, lung infection , and thigh muscle infection .

Application

Products | Products > Disease Areas > Klebsiella Pneumoniae Infection | Products > Disease Areas > Salmonella Infection | Products > Disease Areas > Infection | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Escherichia Coli Infection | Products > Disease Areas > Pseudomonas Aeruginosa Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Antibiotic | Products > Signaling Pathways > Beta-lactamase | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-U00380
• CAS No.: 102507-71-1
• Molecular Formula: C12H15N5O9S2
• Molecular Weight: 437.41
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source