O6-Benzylguanine

Overview

O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis . Antineoplastic activity.

Application

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Product Information

• Catalog No.: HY-W002585
• CAS No.: 19916-73-5
• Molecular Formula: C12H11N5O
• Molecular Weight: 241.25
• Purity: 99.92%
• Storage: RT, protect from light. In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.75 mg/mL (11.40 mM); Clear solution
• Availability: In-stock

Source

Original product source