3-Methylthiophene-2-carboxylic acid

Overview

3-Methylthiophene-2-carboxylic acid (compound 3) is a potent Pseudomonas quinolone signal system protein E ( PqsE ) inhibitor with a K d of 19.6 µM and an IC 50 of 40 µM. 3-Methylthiophene-2-carboxylic acid binds to the active center of PqsE and shows inhibition of the thioesterase activity. Methylthiophene-2-carboxylic acid can permeate into P. aeruginosa and affect 2,4-dihydroxyquinoline (DHQ) levels to a similar extent as deletion of the PqsE gene. 3-Methylthiophene-2-carboxylic acid can be used for cystic fibrosis research.

Application

Products | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Cystic Fibrosis | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-W004782
• CAS No.: 23806-24-8
• Molecular Formula: C6H6O2S
• Molecular Weight: 142.18
• Purity: 99.98%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source