TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC 50 s of 34.2 and 32.9 μM for Tb PTR1 and Lm PTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei ( IC 50 : 34.2 μM).
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