2-Oleoylglycerol

Overview

2-Oleoylglycerol (2-OG) is a lipid found in the diet. It is a GPR119 agonist, with an EC 50 value of 2.5 μM in activating hGPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol enhances the inflammatory response of macrophages and promotes fibrosis by activating the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. It also stimulates glucagon-like peptide 1 ( GLP-1 ) secretion in vivo. 2-Oleoylglycerol is expected to be used in the research of non-alcoholic steatohepatitis (NASH) .

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > GLP Receptor | Products > Signaling Pathways > GPR119 | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > TGF-beta/Smad

Product Information

• Catalog No.: HY-W011121
• CAS No.: 3443-84-3
• Molecular Formula: C21H40O4
• Molecular Weight: 356.55
• Purity: 99.9%
• Storage: Solution, -20°C, 2 years
• Availability: In-stock

Source

Original product source