N-6-Methyl-2-deoxyadenosine

Overview

N-6-Methyl-2-deoxyadenosine (m6dA) is an adenine nucleoside analogue. N-6-Methyl-2-deoxyadenosine targets nuclear processes and DNA replication machineries including WER , SATB1 , TFAM , Jumu , SSBP1 , DNA polymerase η and phage polymerase Gp90 exo − . N-6-Methyl-2-deoxyadenosine acts as a multifunctional epigenetic regulator that modulates transcription, DNA damage response, cell cycle, transposon silencing, stress adaptation, epigenetic crosstalk, and nucleosome organization in both prokaryotes and eukaryotes. N-6-Methyl-2-deoxyadenosine regulates mitochondrial epigenetic inheritance and is required for fear extinction memory in mice. N-6-Methyl-2-deoxyadenosine exhibits dysregulated levels in cancers. N-6-Methyl-2-deoxyadenosine can be used for the research of glioblastoma, triple negative breast cancer , and conditioned fear (fear extinction impairment).

Application

Products | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Glioma | Products > Disease Areas > Anxiety or Fear-Related Disease | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Glioblastoma | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Nucleoside Antimetabolite/Analog | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-W011725
• CAS No.: 2002-35-9
• Molecular Formula: C11H15N5O3
• Molecular Weight: 265.27
• Purity: 99.83%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (9.42 mM); Clear solution
• Availability: In-stock

Source

Original product source