Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm , Lymphatic filariae , and nematode infection . Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC 50 of 120 nM.
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