Methylhydroquinone

Overview

Methylhydroquinone is an orally active COX inhibitor with IC 50 s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2 , respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Environmental Pollutants | Products > Signaling Pathways > COX

Product Information

• Catalog No.: HY-W012817
• CAS No.: 95-71-6
• Molecular Formula: C7H8O2
• Molecular Weight: 124.14
• Purity: 99.91%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 5 mg/mL (40.28 mM); Clear solution
• Availability: In-stock

Source

Original product source