2′-Deoxy-GDP (dGDP) trisodium, a guanosine monophosphate (GMP) analogue, is a hypoxanthine phosphoribosyltransferase (HGPRT) inhibitor with an IC 50 of 12.5 μM. HGPRT is a central enzyme in the purine recycling pathway of all protozoan parasites.
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