Phthalide is a chemical scaffold. Phthalide derivatives act as potent blood-brain barrier modulators. Phthalide exhibits significant anti-inflammatory activity. Some phthalide derivatives possess anti-inflammatory activity. The phthalide derivative Senkyunolide I shows analgesic effects and ameliorates cerebral edema and cerebral infarction volume in rats with focal cerebral ischemia-reperfusion injury. Phthalide can be used in research related to glioma, rheumatoid arthritis, malaria, bacterial infection , fungal infection and ischemic stroke.
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