MZ 1

Overview

MZ 1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 . MZ 1 potently and rapidly induces reversible, long-lasting, and selective removal of BRD4 over BRD2 and BRD3. K d s of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2 , BRD3 BD1/2, and BRD2 BD1/2, respectively. (Pink: BRD4(BD1BD2) ligand ( HY-13030 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-140189 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-107425
• CAS No.: 1797406-69-9
• Molecular Formula: C49H60ClN9O8S2
• Molecular Weight: 1002.64
• Purity: 99.86%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (2.49 mM); Clear solution
• Availability: In-stock

Source

Original product source