Sodium α-ketoisocaproate-d 3

Overview

Sodium α-ketoisocaproate -d3 (Sodium 4-methyl-2-oxopentanoate-d3; 2-Ketoisocaproic acid-d3 (sodium salt)) is the deuterated-labeled Sodium α-ketoisocaproate ( HY-W017387 ). Sodium α-ketoisocaproate (Sodium 4-methyl-2-oxopentanoate) is an insulin secretagogue. Sodium α-ketoisocaproate undergoes transamination catalyzed by BCAT and BCATm to produce α-ketoglutarate and leucine; it also binds to the SUR1 site to inhibit K ATP channel activity, but does not directly affect the Kir6.2 subunit. Sodium α-ketoisocaproate regulates Ca 2+ influx. Sodium α-ketoisocaproate exerts insulinotropic activity in pancreatic islets and intact mouse pancreata with sufficient BCATm expression. Sodium α-ketoisocaproate can be used in research related to type 2 diabetes.

Application

Products | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Type 2 Diabetes | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > Branched Chain Amino Acid Transaminase (BCAT) | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > Na+/Ca2+ Exchanger

Product Information

• Catalog No.: HY-W017387S
• CAS No.: 93523-67-2
• Molecular Formula: C6H6D3NaO3
• Molecular Weight: 155.14
• Purity: 98.48%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source