L-Asparagine-1,2,3,4- 13 C 4 monohydrate

Overview

L-Asparagine-1,2,3,4- 13 C 4 monohydrate is the 13 C labeled labeled L-Asparagine monohydrate ( HY-W017443 ). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase . L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis . L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase ( AASNS ) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > Endogenous Metabolite | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-W017443S4
• CAS No.: 768348-44-3
• Molecular Formula: 13C4H8N2O3
• Molecular Weight: 136.09
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source