1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine

Overview

1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is an oxidized phospholipid. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine reduces the viability of HUVECs, increases the levels of ferrous ions and lipid peroxidation, promotes the production of superoxide anions, and decreases the levels of glutathione and GPX4 in cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine upregulates the mRNA and protein levels of FABP3 in HUVECs, impairs mitochondrial membrane potential, and induces ferroptosis -related changes as well as mitochondrial dysfunction and damage. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine activates caspase-11 and promotes the continuous release of IL-1β from macrophages and dendritic cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine inhibits the proliferation of aortic smooth muscle cells and induces apoptosis in these cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is applicable to relevant research on atherosclerosis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Atherosclerosis and Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > FABP | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-W040255
• CAS No.: 89947-79-5
• Molecular Formula: C29H56NO10P
• Molecular Weight: 609.73
• Purity: 99.68%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source