Xipamide

Overview

Xipamide is an orally active carbonic anhydrase ( CA ) inhibitor and Na + /Cl - -potassium transporter inhibitor with diuretic and antihypertensive effects. Xipamide reduces NaCl reabsorption by inhibiting the Cl - /NaCO 3 - anion exchanger , and increases calcium reabsorption while promoting potassium and magnesium excretion. Xipamide is mainly cleared via the renal pathway and causes a temporary decrease in glomerular filtration rate under specific conditions. Xipamide does not affect Ca 2+ signaling induced by endothelin-1 and other factors, nor does it inhibit various ion cotransport or pump activities in red blood cells. Xipamide can be used in researches related to cardiovascular diseases, hypertension (especially with left ventricular hypertrophy), advanced renal failure, and liver cirrhosis with ascites.

Application

Products | Products > Disease Areas > Hypertension | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Anion Exchangers | Products > Signaling Pathways > Carbonic Anhydrase | Products > Signaling Pathways > Endothelin Receptor

Product Information

• Catalog No.: HY-W042301
• CAS No.: 14293-44-8
• Molecular Formula: C15H15ClN2O4S
• Molecular Weight: 354.81
• Purity: 99.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (5.86 mM); Clear solution
• Availability: In-stock

Source

Original product source