9-Methyl-β-carboline

Overview

9-Methyl-β-carboline is a monoamine oxidase inhibitor and dopaminergic modulator, with an IC 50 of 1 μM against human MAO-A and an IC 50 of 15.5 μM against human MAO-B . 9-Methyl-β-carboline possesses cognitive enhancement potential and can cross the blood-brain barrier. 9-Methyl-β-carboline increases dopamine levels by inhibiting monoamine oxidase activity and microglial proliferation. 9-Methyl-β-carboline activates PKA/PKC and mitochondrial respiratory chain complex I, promotes neurotrophic factor expression and reduces α-synuclein ( α-synuclein ) levels, thereby reversing neurotoxin-induced dopaminergic neuron damage. 9-Methyl-β-carboline also regulates the PI3K pathway and exerts an anti-proliferative effect on astrocytes. 9-Methyl-β-carboline is widely used in Parkinson's disease-related studies.

Application

Products | Products > Disease Areas > Parkinson's Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Dopamine Receptor | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Monoamine Oxidase

Product Information

• Catalog No.: HY-W049881
• CAS No.: 2521-07-5
• Molecular Formula: C12H10N2
• Molecular Weight: 182.22
• Purity: 99.86%
• Storage: Store at room temperature 3 years. In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 5 mg/mL (27.44 mM); Clear solution
• Availability: In-stock

Source

Original product source