Norquetiapine

Overview

Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine ( HY-14544 ), is a selective HCN1 channel inhibitor, with an IC 50 of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT 1A ( K i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 ( K i = 237 nM), 5-HT 2C ( K i = 107 nM), and 5-HT 7 ( K i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS ( HY-D1056 ) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation.

Application

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Product Information

• Catalog No.: HY-W052508
• CAS No.: 5747-48-8
• Molecular Formula: C17H17N3S
• Molecular Weight: 295.41
• Purity: 99.95%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (8.46 mM); Clear solution
• Availability: In-stock

Source

Original product source