Norquetiapine-d 8

Overview

Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine ( HY-14544 ), is a selective HCN1 channel inhibitor, with an IC 50 of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT 1A ( K i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 ( K i = 237 nM), 5-HT 2C ( K i = 107 nM), and 5-HT 7 ( K i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS ( HY-D1056 ) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Others | Products > Signaling Pathways > Isotope-Labeled Compounds

Product Information

• Catalog No.: HY-W052508S
• CAS No.: 1189866-35-0
• Molecular Formula: C17H9D8N3S
• Molecular Weight: 303.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source