Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC 50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) ( IC 50 =64.8 μM) and T. brucei ( EC 50 =1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity.
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