RO8191

Overview

RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC 50 of 200 nM for HCV replicon. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti- HBV activity.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > STAT | Products > Signaling Pathways > HCV | Products > Signaling Pathways > HBV | Products > Signaling Pathways > IFNAR | Products > Signaling Pathways > JAK

Product Information

• Catalog No.: HY-W063968
• CAS No.: 691868-88-9
• Molecular Formula: C14H5F6N5O
• Molecular Weight: 373.21
• Purity: 98.80%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: 0.5 mg/mL (1.34 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source