nAChR-IN-2 (Compound 2) is an inhibitor of insect nicotinic acetylcholine receptors ( nAChR ). nAChR-IN-2 inhibits the binding of α-bungarotoxin ( HY-P1264 ) to the ACh site of insect nAChR in honeybee heads, with an IC 50 of 360 μM. nAChR-IN-2 also inhibits the binding of Phencyclidine to the NCB/PCP site of insect nAChR in honeybee heads, with an IC 50 of 84 μM.
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