UK-370106

Overview

UK-370106 is a potent and highly selective MMP-3 ( IC 50 of 23 nM) and MMP-12 ( IC 50 of 42 nM) inhibitor with >1200-fold higher potency than MMP-1 , MMP-2 , MMP-9 , and MMP-14 , and about 100-fold than MMP-13 and MMP-8 . UK-370106 potently inhibits cleavage of [ 3 H]-fibronectin by MMP-3 ( IC 50 of 320 nM) and has little effect on keratinocyte migration in vitro.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MMP

Product Information

• Catalog No.: HY-107639
• CAS No.: 230961-21-4
• Molecular Formula: C35H44N2O5
• Molecular Weight: 572.73
• Purity: 96.70%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (8.73 mM); Clear solution
• Availability: In-stock

Source

Original product source