Milameline hydrochloride

Overview

Milameline (CI 979; RU35926) hydrochloride is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydrochloride has equal affinity for different subtypes of human muscarinic receptors with IC 50 of 1.3 µM for M1- , 1.1 µM for M2- , 1.5 µM for M3- , and 1.9 µM for M4-muscarinic receptors . Milameline hydrochloride has a higher affinity for sites [ 3 H]CMD ( IC 50 = 20 nM), than [ 3 H]QNB, ( IC 50 = 3059 nM). Milameline hydrochloride produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydrochloride can be used for the study of Alzheimer’s Disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mAChR

Product Information

• Catalog No.: HY-107650
• CAS No.: 139886-04-7
• Molecular Formula: C8H15ClN2O
• Molecular Weight: 190.67
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source