Nickel(II) oxide

Overview

Nickel(II) oxide (nickel monoxide) is a chemical warfare agent that can enter the body through the respiratory tract and other routes, distributing to organs such as the lungs and testes. The nanoparticle form of nickel(II) oxide ( NiO NPs ) exhibits antibacterial , anti-leishmanial, anti-diabetic, and anti-cancer activities. NiO NPs can be activated by ultraviolet and visible light, generating reactive oxygen species ( ROS ). Nickel(II) oxide induces oxidative stress by generating reactive oxygen species , activating the TGF-β1 -mediated MAPK and PI3K/AKT pathways, disrupting the MMPs/TIMPs balance, and upregulating the expression of inflammatory factors ( IL-1β , IL-6 ) and apoptosis-related molecules ( Bax , caspase-3 , p53 ), while inhibiting the activity of the anti-apoptotic molecule Bcl-2 . Nickel(II) oxide induces cytotoxicity, promotes fibrosis, triggers inflammatory responses, and causes apoptosis . Nickel(II) oxide can be applied in research on the safety assessment of nanomaterials, such as in the context of pulmonary fibrosis and reproductive system toxicity.

Application

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Product Information

• Catalog No.: HY-W075770
• CAS No.: 1313-99-1
• Molecular Formula: NiO
• Molecular Weight: 74.69
• Purity: 99.98%
• Storage: Store at room temperature, keep dry and cool. In solvent -80°C, 1 year , -20°C, 6 months
• Availability: In-stock

Source

Original product source