NOTA-NHS ester is a chelating agent. NOTA-NHS ester can be coupled with T140 ( HY-P4810 ) to produce NOTA-T140. NOTA-T140 can be radiolabeled with Al[ 18 F]. The uptake of Al[ 18 F]NOTA-T140 in tumors is correlated with the expression level of CXCR4 . Al[ 18 F]NOTA-T140 can be used in tumor PET imaging studies. NOTA-NHS ester can be used for fluorescent labeling.
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