threo Ifenprodil hemitartrate is a σ receptor agonist, with K i s of 59.1 and 2 nM for σ1 and σ2 receptors, respectively. threo Ifenprodil hemitartrate is also a NR2B subunit-selective NMDA receptor antagonist ( IC 50 =0.22 μM). threo Ifenprodil hemitartrate is a hERG potassium channel inhibitor , with an IC 50 of 88 nM, showing antiarrhythmic activity.
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