N-Methylthalidomide

Overview

N-Methylthalidomide is a cereblon ligand derivative that acts as an E3 ubiquitin ligase ligand for the synthesis of PROTAC LLC0424 N ( HY-185557 ). LLC0424 N serves as a negative control for NSD2 PROTAC degrader LLC0424 ( HY-161574 ), with weak ability to induce NSD2 degradation and low growth inhibitory effect on cancer cells carrying NSD2 mutations.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Ligands for E3 Ligase

Product Information

• Catalog No.: HY-W1005059
• CAS No.: 42472-93-5
• Molecular Formula: C14H12N2O4
• Molecular Weight: 272.26
• Purity: 98.0%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source