KU-60019

Overview

KU-60019 is a potent and selective ATM inhibitor. KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells Source summary: KU-60019 is a research-use small-molecule inhibitor for cell cycle studies; used in biochemical and molecular biology assays.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | ATM

Product Information

• Catalog No.: B2693-286438
• CAS No.: 925701-49-1
• Molecular Formula: C30H33N3O5S
• Molecular Weight: 547.67
• Purity: 98%
• Storage: Store at -20°C
• Solubility: Soluble in DMSO (100 mM), and ethanol (100 mM).

Source

Original product source