Talotrexin

Overview

Talotrexin (PT523), an analog of Aminopterin ( HY-14518 ), is a nonpolyglutamatable classic antifolate . Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Antifolate | Products > Signaling Pathways > Dihydrofolate reductase (DHFR)

Product Information

• Catalog No.: HY-10824
• CAS No.: 113857-87-7
• Molecular Formula: C27H27N9O6
• Molecular Weight: 573.56
• Purity: 99.27%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source