Spliceostatin A

Overview

Spliceostatin A is a potent inhibitor of in vitro and in vivo pre-mRNA splicing. It was shown to inhibit splicing and to interact with an essential component of the spliceosome, SF3b. Spliceostatin A is an inhibitor of RNA synthesis with excellent anticancer activity against a variety of human cancer cell lines. Spliceostatin A inhibits mitotic clone expansion and adipogenesis. Source summary: Spliceostatin A is an ADC payload that inhibits spliceosome function, providing a novel mechanism for cancer cell targeting.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | DNA/RNA Synthesis

Product Information

• Catalog No.: B2693-335149
• CAS No.: 391611-36-2
• Molecular Formula: C28H43NO8
• Molecular Weight: 521.64
• Purity: ≥95% by HPLC
• Storage: Store at -80 °C, dry and sealed storage
• Solubility: Soluble in DMSO

Source

Original product source