PLK1-IN-9

Overview

PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 ( PLK1 ), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC 50 s of 1.6, 0.8 and 1.4 μM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis . PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Polo-like Kinase (PLK)

Product Information

• Catalog No.: HY-W276819
• CAS No.: 893772-67-3
• Molecular Formula: C12H7F3N4O2
• Molecular Weight: 296.20
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source