Cytarabine 5’-monophosphate

Overview

Cytarabine 5′-monophosphate is a metabolite of the nucleoside analog Cytarabine ( HY-13605 ), catalyzed by deoxycytidine kinase. Cytarabine 5′-monophosphate is incorporated into DNA by DNA polymerase α, which reduces the rate of DNA synthesis. At a concentration of 15 mM, Cytarabine 5′-monophosphate inhibits nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae ( S. cerevisiae ). Additionally, Cytarabine 5′-monophosphate (3.5-75.1 mg/kg) improves survival in leukemia mice (L1210 mice). Cytarabine 5′-monophosphate can be used in cancer research.

Application

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Product Information

• Catalog No.: HY-W344074
• CAS No.: 7075-11-8
• Molecular Formula: C9H14N3O8P
• Molecular Weight: 323.20
• Purity: 98.04%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Availability: In-stock

Source

Original product source